| Multifocal, mucosal, cutaneous and muscular venous malformations with no family history. It is associated with double pathogenic variants in the TEK (TIE2) gene, where the first is mosaic and detectable at low frequency in blood DNA and the second is somatic in the lesion. Although the mosaic substrate is congenital, individual lesions may not all be present at birth and new lesions can develop over time. |
